I don’t subscribe to these hypotheses, but they are interesting to ponder:
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Depression is neither an illness nor a disorder, but rather an adaptation that has evolved to serve a purpose.
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Depression is so much more common than currently believed that it is “species typical.”
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Antidepressants cause neurotransmitter levels so high that homeostatic regulation comes into play
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Antidepressants may suppress symptoms in a way that increases the risk of later relapse
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Cognitive therapy works by making rumination more effective and “unstuck” self-blame
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Adding antidepressants may interfere with any lasting effects that cognitive therapy may have
These come from a new article by Steven D. Hollon.